Analytical and Sample Preparation Protocol for Therapeutic Drug Monitoring of 12 Thiopurine Metabolites Related to Clinical Treatment of Inflammatory Bowel Disease

Analytical and Sample Preparation Protocol for Therapeutic Drug Monitoring of 12 Thiopurine Metabolites Related to Clinical Treatment of Inflammatory Bowel Disease

Thiopurines (TP) represent an important therapeutic tool for the treatment of inflammatory bowel diseases (IBD) in the current situation of rising incidence and health care costs. The results of multiple clinical studies aimed at finding correlations between levels of TP metabolites and response of...

Full description

Bibliographic Details
Main Authors: Daniel Pecher, Svetlana Dokupilová, Zuzana Zelinková, Maikel Peppelenbosch, Jana Lučeničová, Veronika Mikušová, Peter Mikuš
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
inflammatory bowel diseases
therapeutic drug monitoring
profiling of thiopurines
comprehensive stability study
sample treatment
clinical analysis
high performance liquid chromatography
mass spectrometry
Online Access:http://www.mdpi.com/1420-3049/23/7/1744

Internet

http://www.mdpi.com/1420-3049/23/7/1744

Similar Items