Integrin-Matrix Clusters Form Podosome-like Adhesions in the Absence of Traction Forces

Integrin-Matrix Clusters Form Podosome-like Adhesions in the Absence of Traction Forces

Matrix-activated integrins can form different adhesion structures. We report that nontransformed fibroblasts develop podosome-like adhesions when spread on fluid Arg-Gly-Asp peptide (RGD)-lipid surfaces, whereas they habitually form focal adhesions on rigid RGD glass surfaces. Similar to classic ma...

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Bibliographic Details
Main Authors: Cheng-han Yu, Nisha Bte Mohd Rafiq, Anitha Krishnasamy, Kevin L. Hartman, Gareth E. Jones, Alexander D. Bershadsky, Michael P. Sheetz
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713006396

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http://www.sciencedirect.com/science/article/pii/S2211124713006396

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