Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice

Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice

Histone deacetylase 9 (HDAC9) is expressed in B cells, and its overexpression has been observed in B-lymphoproliferative disorders, including B-cell non-Hodgkin lymphoma (B-NHL). We examined HDAC9 protein expression and copy number alterations in primary B-NHL samples, identifying high HDAC9 express...

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Bibliographic Details
Main Authors: Veronica S. Gil, Govind Bhagat, Louise Howell, Jiyuan Zhang, Chae H. Kim, Sven Stengel, Francisco Vega, Arthur Zelent, Kevin Petrie
Format: Article
Language:English
Published: The Company of Biologists 2016-12-01
Series:Disease Models & Mechanisms
Subjects:
HDAC9
Lymphoma
Transgenic mouse
Online Access:http://dmm.biologists.org/content/9/12/1483

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