Rifaximin improves Clostridium difficile toxin A-induced toxicity in Caco-2 cells by the PXR-dependent TLR4/MyD88/NF-κB pathway

Rifaximin improves Clostridium difficile toxin A-induced toxicity in Caco-2 cells by the PXR-dependent TLR4/MyD88/NF-κB pathway

Background: Clostridium difficile infections (CDIs) caused by Clostridium difficile toxin A (TcdA) lead to severe ulceration, inflammation and bleeding of the colon, and are difficult to treat.Aim: The study aimed to evaluate the effect of rifaximin on TcdA-induced apoptosis in intestinal epithelial...

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Bibliographic Details
Main Authors: Giuseppe eEsposito, Nicola eNobile, Stefano eGigli, Luisa eSeguella, Marcella ePesce, Alessandra eD'Alessandro, Eugenia eBruzzese, Elena eCapoccia, Luca eSteardo, Rosario eCuomo, Giovanni eSarnelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Pharmacology
Subjects:
Caco-2 Cells
Pseudomembranous colitis
Pregnane X receptor
Clostridium difficile toxin A
rifaximin.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00120/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00120/full

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