Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ

Crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) have revealed overlapping binding modes for synthetic and natural/endogenous ligands, indicating competition for the orthosteric pocket. Here we show that cobinding of a synthetic ligand to the orthosteric pocket can push...

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Bibliographic Details
Main Authors: Jinsai Shang, Richard Brust, Sarah A Mosure, Jared Bass, Paola Munoz-Tello, Hua Lin, Travis S Hughes, Miru Tang, Qingfeng Ge, Theodore M Kamenekca, Douglas J Kojetin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
nuclear receptors
nuclear magnetic resonance
x-ray crystallography
ligand binding
transcription factors
Online Access:https://elifesciences.org/articles/43320

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