Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients

Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients

Abstract Background Developing novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due to close proximity of cerebrospinal fluid (CSF) to affected tissues. Dev...

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Bibliographic Details
Main Authors: Lucas R. Sass, Mohammadreza Khani, Jacob Romm, Marianne Schmid Daners, Kyle McCain, Tavara Freeman, Gregory T. Carter, Douglas L. Weeks, Brian Petersen, Jason Aldred, Dena Wingett, Bryn A. Martin
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Fluids and Barriers of the CNS
Subjects:
Cerebrospinal fluid
Amyotrophic lateral sclerosis
Magnetic resonance imaging
Intrathecal drug delivery
Spinal cord
Online Access:https://doi.org/10.1186/s12987-019-0164-3

Internet

https://doi.org/10.1186/s12987-019-0164-3

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