MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations

How mutations in the microtubule-associated protein tau (MAPT) gene cause frontotemporal dementia (FTD) remains poorly understood. We generated and characterized multiple induced pluripotent stem cell (iPSC) lines from patients with MAPT IVS10+16 and tau-A152T mutations and a control subject. In cor...

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Bibliographic Details
Main Authors: Md Helal U. Biswas, Sandra Almeida, Rodrigo Lopez-Gonzalez, Wenjie Mao, Zhijun Zhang, Anna Karydas, Michael D. Geschwind, Jacek Biernat, Eva-Maria Mandelkow, Kensuke Futai, Bruce L. Miller, Fen-Biao Gao
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Stem Cell Reports
Subjects:
frontotemporal dementia
iPSCs
MMP-2
MMP-9
neuronal survival
neurons
tau
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116301734

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http://www.sciencedirect.com/science/article/pii/S2213671116301734

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