Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase

Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase

A ceramide deficiency in the stratum corneum (SC) is an essential etiologic factor for the dry and barrier-disrupted skin of patients with atopic dermatitis (AD). Previously, we reported that sphingomyelin (SM) deacylase, which hydrolyzes SM and glucosylceramide at the acyl site to yield their lysof...

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Bibliographic Details
Main Authors: Yasuhiro Teranishi, Hiroshi Kuwahara, Masaru Ueda, Tadashi Takemura, Masanori Kusumoto, Keiji Nakamura, Jun Sakai, Toru Kimura, Yasuji Furutani, Makoto Kawashima, Genji Imokawa, Mari Nogami-Itoh
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
atopic dermatitis
ceramide
ceramide deficiency
barrier function
water reservoir faction
stratum corneum
Online Access:https://www.mdpi.com/1422-0067/21/22/8789

Internet

https://www.mdpi.com/1422-0067/21/22/8789

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