SUV39 SET domains mediate crosstalk of heterochromatic histone marks

SUV39 SET domains mediate crosstalk of heterochromatic histone marks

The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin. How these enzymes are regulated to mark specific genomic regions as heterochromatic is poorly understood. Clr4 is the sole H3K9me2/3 methyltrans...

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Bibliographic Details
Main Authors: Alessandro Stirpe, Nora Guidotti, Sarah J Northall, Sinan Kilic, Alexandre Hainard, Oscar Vadas, Beat Fierz, Thomas Schalch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
heterochromatin
methyltransferase
ubiquitin
posttranslational modifications
enzyme kinetics
protein complex
Online Access:https://elifesciences.org/articles/62682

Internet

https://elifesciences.org/articles/62682

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