The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain

The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain

Opioid activation of the mu opioid receptor (MOR) promotes signaling cascades that evoke both analgesic responses to pain and side effects like addiction and dependence. Manipulation of these cascades, such as by biased agonism, has great promise to improve opioid therapy. However, the signaling cas...

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Bibliographic Details
Main Authors: Wei Lei, David I. Duron, Carrie Stine, Sanket Mishra, Brian S. J. Blagg, John M. Streicher
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
heat shock protein 90 (Hsp90)
p23
Cdc37
opioid
pain
anti-nociception
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00294/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00294/full

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