Nanolipoparticles-mediated MDR1 siRNA delivery: preparation, characterization and cellular uptake

Objective(s): Lipid-based nanoparticles (NLP) are PEGylated carriers composed of lipids and encapsulated nucleic acids with a diameter less than 100 nm. The presence of PEG in the NLP formulation improves the particle pharmacokinetic behavior. The purpose of this study was to prepare and characteriz...

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Bibliographic Details
Main Authors: Mahnaz Nourbakhsh, Javad Behravan, Hermann Lage, Khalil Abnous, Fatemeh mosaffa, Ali Badiee, Mahmoud R. Jaafari
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2015-01-01
Series:Nanomedicine Journal
Subjects:
Online Access:http://nmj.mums.ac.ir/pdf_3467_c5d9c11f9ed269c7e3041f316fa5bb82.html