Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved

Alzheimer's disease (AD) and Parkinson's disease (PD) are age-associated neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn) and tau, respectively. The coexistence of aSyn and tau aggregates suggests a strong overlap between tauopathies and...

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Bibliographic Details
Main Authors: Eftychia Vasili, Antonio Dominguez-Meijide, Tiago Fleming Outeiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
tau
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00107/full