Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway

Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway

Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths. However, it is unclear whether Ku80 regulates tumor growth in human melanoma. In this study, we screened a siRNA library targeting 6024 human genes and identified Ku80 as a potential therapeutic target in m...

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Bibliographic Details
Main Authors: Tianze Liu, Lizi Jin, Miao Chen, Zongheng Zheng, Wenjing Lu, Wenhua Fan, Liren Li, Fufu Zheng, Qiaohua Zhu, Huijuan Qiu, Jiani Liu, Manyu Chen, Chunfang Tian, Zheng Hu, Changlin Zhang, Meihua Luo, Jian Li, Tiebang Kang, Lukun Yang, Yizhuo Li, Wuguo Deng
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718310309

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http://www.sciencedirect.com/science/article/pii/S2213231718310309

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