Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance

Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance

Accumulation of the amyloid-beta (Ab) peptide is a central factor in Alzheimer’s disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Ab in AD before discussing the clearance of this peptide. Mechanisms of cleara...

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Bibliographic Details
Main Authors: Robert eMarr, Daniel eHafez
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Neprilysin
amyloid hypothesis
Clearance
Alzheimer’s disease.
NEP
neprilysin-2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00187/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00187/full

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