Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes

Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes

Abstract Background Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutations affecting UBE3A gene expression. Previous studies in mice revealed distinct critical periods during neurodevelopment in which reactivation of Ube3a gene expression can prevent the onset of behavior...

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Bibliographic Details
Main Authors: Monica Sonzogni, Johanna Hakonen, Mireia Bernabé Kleijn, Sara Silva-Santos, Matthew C. Judson, Benjamin D. Philpot, Geeske M. van Woerden, Ype Elgersma
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Molecular Autism
Subjects:
Ube3a
Angelman syndrome
Mouse model
Seizure
Autism spectrum disorder
Phenotype
Online Access:http://link.springer.com/article/10.1186/s13229-019-0277-1

Internet

http://link.springer.com/article/10.1186/s13229-019-0277-1

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