DC-SIGN Binding Contributed by an Extra N-Linked Glycosylation on Japanese Encephalitis Virus Envelope Protein Reduces the Ability of Viral Brain Invasion

DC-SIGN Binding Contributed by an Extra N-Linked Glycosylation on Japanese Encephalitis Virus Envelope Protein Reduces the Ability of Viral Brain Invasion

The major structural envelope (E) protein of Japanese encephalitis virus (JEV) facilitates cellular binding/entry and is the primary target of neutralizing antibodies. JEV E protein has one N-linked glycosylation site at N154 (G2 site), but the related dengue virus E protein has two glycosylation si...

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Bibliographic Details
Main Authors: Jian-Jong Liang, Min-Wei Chou, Yi-Ling Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Japanese encephalitis virus
envelope protein
glycosylation
vaccine potential
DC-SIGN
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00239/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00239/full

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