Immunization With a DNA Vaccine Encoding the Toxoplasma gondii’ s GRA39 Prolongs Survival and Reduce Brain Cyst Formation in a Murine Model

Immunization With a DNA Vaccine Encoding the Toxoplasma gondii’ s GRA39 Prolongs Survival and Reduce Brain Cyst Formation in a Murine Model

Toxoplasma gondii, an obligate intracellular protozoan parasite, can cause infect almost all warm-blooded animals and humans. To evaluate the immunogenicity and protective efficacy of T. gondii GRA39 (TgGRA39) in mice by using DNA immunization, we constructed a recombinant eukaryotic plasmid pVAX-Tg...

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Bibliographic Details
Main Authors: Yuchao Zhu, Yanan Xu, Lu Hong, Chunxue Zhou, Jia Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Microbiology
Subjects:
Toxoplasma gondii
GRA39
DNA vaccine
toxoplasmosis
Th1
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.630682/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.630682/full

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