Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.

Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.

Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation, fibrosis, and wound healing by enhancing L-proline, polyamine, and Th2 cytokine production. Here, however, we show that macrophage-specific Arg1 functions as an inhibitor of inflammation and fibrosis following...

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Bibliographic Details
Main Authors: John T Pesce, Thirumalai R Ramalingam, Margaret M Mentink-Kane, Mark S Wilson, Karim C El Kasmi, Amber M Smith, Robert W Thompson, Allen W Cheever, Peter J Murray, Thomas A Wynn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2660425?pdf=render

Internet

http://europepmc.org/articles/PMC2660425?pdf=render

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