Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8+ T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease

Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8+ T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease

Recurrent viral diseases often occur after the viruses evade the hosts' immune system, by inducing exhaustion of antiviral T cells. In the present study, we found that functionally exhausted herpes simplex virus type 1 (HSV-1) -specific CD8+ T cells, with elevated expression of lymphocyte activ...

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Bibliographic Details
Main Authors: Soumyabrata Roy, Pierre-Grégoire Coulon, Ruchi Srivastava, Hawa Vahed, Grace J. Kim, Sager S. Walia, Taikun Yamada, Mona A. Fouladi, Vincent T. Ly, Lbachir BenMohamed
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
herpes simplex type 1
CD8+ T cells
LAG-3
immune check point
recurrent
therapeutic
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02922/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02922/full

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