Protocol for the preparation of site-specific succinylated histone mimics to investigate the impact on nucleosome dynamics

Summary: Lysine succinylation is a recently discovered posttranslational modification that plays critical roles in metabolism, epigenetic signaling, and human diseases. To investigate the effects of site-specific histone lysine succinylation on nucleosome dynamics requires the generation of homogene...

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Bibliographic Details
Main Authors: Yihang Jing, Zheng Liu, Xiang David Li
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166721003117