Increased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy

Rationale: Hypertrophic cardiomyopathy (HCM) occurs in ~0.5% of the population and is a leading cause of sudden cardiac death (SCD) in young adults. Cardiomyocyte hypertrophy has been the accepted mechanism for cardiac enlargement in HCM, but the early signaling responsible for initiating hypertroph...

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Bibliographic Details
Main Authors: Emily T. Farrell, Adrian C. Grimes, Willem J. de Lange, Annie E. Armstrong, J. Carter Ralphe
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Physiology
Subjects:
HCM
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00414/full