Patients with Congenital Limb Anomaly Show Short Telomere, Shutdown of Telomerase and Deregulated Expression of Various Telomere-Associated Proteins in Peripheral Blood Mononuclear Cells-A Case Series

Patients with Congenital Limb Anomaly Show Short Telomere, Shutdown of Telomerase and Deregulated Expression of Various Telomere-Associated Proteins in Peripheral Blood Mononuclear Cells-A Case Series

Congenital limb anomalies are outcome of improper bone formation during embryonic development when cells divide, differentiate with high rate. So, telomerase activity is essential to maintain telomere length for such highly dividing cells. Here, we report four cases of congenital limb anomalies wi...

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Bibliographic Details
Main Authors: Jayitri Mazumdar, Priyanka Chowdhury, Tunisha Bhattacharya, Badal Chandra Mondal, Utpal Ghosh
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2017-08-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
embryonic developement
telomeropathy
telomere length
hterc
shelterin protein
Online Access:https://jcdr.net/articles/PDF/10516/26960_CE[Ra]_F(Sh)_PF1(NE_VT_GG)_PFA(NE_GG)_PF2(NE_SS).pdf

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https://jcdr.net/articles/PDF/10516/26960_CE[Ra]_F(Sh)_PF1(NE_VT_GG)_PFA(NE_GG)_PF2(NE_SS).pdf

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