Cotinine prevents memory loss and diminishes Alzheimer's disease-like pathology

Cotinine prevents memory loss and diminishes Alzheimer's disease-like pathology

Alzheimer's disease (AD) affects millions of people around the world and currently there are no effective therapies. Cotinine, a metabolite of nicotine, has been shown to be neuroprotective, prevent memory loss and reduce amyloid-β (Aβ) plaque pathology in transgenic AD mice. The beneficial eff...

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Bibliographic Details
Main Authors: Laura Catalina Charry, George E. Barreto, Valentina Echeverria Moran
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cotinine
Depression
Akt
Alzheimer's disease
memory loss
protein kinase B
amyloid-β
postsynaptic density protein 95
Online Access:http://journal.frontiersin.org/Journal/10.3389/conf.fncel.2015.35.00021/full

Internet

http://journal.frontiersin.org/Journal/10.3389/conf.fncel.2015.35.00021/full

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