ERN1 knockdown modifies the hypoxic regulation of TP53, MDM2, USP7 and PERP gene expressions in U87 glioma cells

ERN1 knockdown modifies the hypoxic regulation of TP53, MDM2, USP7 and PERP gene expressions in U87 glioma cells

Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. Glioma cells w...

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Bibliographic Details
Main Authors: S. V. Danilovskyi, D. O. Minchenko, О. S. Moliavko, O. V. Kovalevska, L. L. Karbovskyi, O. H. Minchenko
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2014-08-01
Series:Ukrainian Biochemical Journal
Subjects:
ERN1
glioma cells
hypoxia
MDM2
mRNA expression
PERP
TP53
USP7
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Danilovskyi_4_14.pdf

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http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Danilovskyi_4_14.pdf

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