Effect of Chromatin Structure on the Extent and Distribution of DNA Double Strand Breaks Produced by Ionizing Radiation; Comparative Study of hESC and Differentiated Cells Lines

Effect of Chromatin Structure on the Extent and Distribution of DNA Double Strand Breaks Produced by Ionizing Radiation; Comparative Study of hESC and Differentiated Cells Lines

Chromatin structure affects the extent of DNA damage and repair. Thus, it has been shown that heterochromatin is more protective against DNA double strand breaks (DSB) formation by ionizing radiation (IR); and that DNA DSB repair may proceed differently in hetero- and euchromatin regions. Human embr...

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Bibliographic Details
Main Authors: Priyanka Venkatesh, Irina V. Panyutin, Evgenia Remeeva, Ronald D. Neumann, Igor G. Panyutin
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
ionizing radiation
human embryonic stem cells
chromatin structure
Online Access:http://www.mdpi.com/1422-0067/17/1/58

Internet

http://www.mdpi.com/1422-0067/17/1/58

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