Inhibition of bcl-2 and cox-2 Protein Expression after Local Application of a New Carmustine-Loaded Clinoptilolite-Based Delivery System in a Chemically Induced Skin Cancer Model in Mice

Inhibition of bcl-2 and cox-2 Protein Expression after Local Application of a New Carmustine-Loaded Clinoptilolite-Based Delivery System in a Chemically Induced Skin Cancer Model in Mice

Our research has focused on in vitro and in vivo evaluations of a new Carmustine (BCNU)-loaded clinoptilolite-based delivery system. Two clinoptilolite ionic forms—hydrogen form (HCLI) and sodium form (NaCLI)—were prepared, allowing a loading degree of about 5–6 mg BCNU/g of zeolite matrix due to th...

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Bibliographic Details
Main Authors: Cristina Mihaela Ghiciuc, Aurel Lulu Strat, Lacramioara Ochiuz, Catalina Elena Lupusoru, Maria Ignat, Aurelia Vasile, Alexandru Grigorovici, Iulian Stoleriu, Carmen Solcan
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
clinoptilolite
zeolite
drug delivery system
skin cream
Carmustine
chemically induced skin cancer
mouse cancer model
cyclooxygenase 2 (cox-2) protein
B-cell lymphoma-2 (bcl-2) protein
quantitative immunohistochemistry
computer aided diagnostic software
Online Access:https://www.mdpi.com/1420-3049/22/11/2014

Internet

https://www.mdpi.com/1420-3049/22/11/2014

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