Glutamate/NMDA excitotoxicity and HMGB1/TLR4 neuroimmune toxicity converge as components of neurodegeneration
Neurodegeneration in brain is linked to both excitotoxicity and neuroimmune gene induction, although the mechanisms are poorly understood. High-mobility group box 1 (HMGB1) is a cytokine like molecule released in brain by glutamate that has been found to enhance neuronal excitability through Toll-li...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2015-03-01
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| Series: | AIMS Molecular Science |
| Subjects: | |
| Online Access: | http://www.aimspress.com/article/10.3934/molsci.2015.2.77/fulltext.html |