Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies

Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies

The novel basic, heat-stable tubulin polymerization promoting protein TPPP/p25 is associated with microtubules in vitro and can induce the formation of aberrant microtubule assemblies. We show by 1H-NMR spectroscopy that TPPP/p25 is natively unfolded. Antisera against peptide 186GKGKAGRVDLVDESG200NH...

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Bibliographic Details
Main Authors: Gábor G. Kovács, Lajos László, János Kovács, Poul Henning Jensen, Evo Lindersson, Gergő Botond, Tamás Molnár, András Perczel, Ferenc Hudecz, Gábor Mező, Anna Erdei, László Tirián, Attila Lehotzky, Ellen Gelpi, Herbert Budka, Judit Ovádi
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Neurobiology of Disease
Subjects:
TPPP/p25
Microtubule
Alpha-synuclein
Tau
Parkinson's disease
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001366

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http://www.sciencedirect.com/science/article/pii/S0969996104001366

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