Benzo(a)pyrene induces MUC5AC expression through the AhR/mitochondrial ROS/ERK pathway in airway epithelial cells

Benzo(a)pyrene induces MUC5AC expression through the AhR/mitochondrial ROS/ERK pathway in airway epithelial cells

Objectives: Benzo(a)pyrene (BaP) is a ubiquitous air pollutants, and BaP exposure leads to a risk of respiratory diseases. The oversecretion of airway mucus and high expression of mucin 5AC (MUC5AC) are associated with common respiratory disorders caused by air pollution. We aimed to investigate the...

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Bibliographic Details
Main Authors: Yipeng Sun, Zhaowen Shi, Yuhua Lin, Mengzhe Zhang, Jinjin Liu, Linyun Zhu, Qingge Chen, Junjie Bi, Shanqun Li, Zhenhua Ni, Xiongbiao Wang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Benzo(a)Pyrene
Mucin 5AC
Aryl hydrocarbon receptor
Reactive oxygen species
Resveratrol
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320316936

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http://www.sciencedirect.com/science/article/pii/S0147651320316936

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