Early Gabapentin Treatment during the Latency Period Increases Convulsive Threshold, Reduces Microglial Activation and Macrophage Infiltration in the Lithium-Pilocarpine Model of Epilepsy

Early Gabapentin Treatment during the Latency Period Increases Convulsive Threshold, Reduces Microglial Activation and Macrophage Infiltration in the Lithium-Pilocarpine Model of Epilepsy

The lithium-pilocarpine model of epilepsy reproduces several features of temporal lobe epilepsy in humans, including the chronological timeline of an initial latency period followed by the development of spontaneous seizures. Epilepsy therapies in humans are implemented, as a rule, after the onset o...

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Bibliographic Details
Main Authors: Alicia Rossi, Veronica Murta, Jerónimo Auzmendi, Alberto Javier Ramos
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Pharmaceuticals
Subjects:
epilepsy
latency period
reactive gliosis
synaptogenesis
epileptogenesis
Online Access:https://www.mdpi.com/1424-8247/10/4/93

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https://www.mdpi.com/1424-8247/10/4/93

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