Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability

Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability

Abstract Background Centromeric regions of human chromosomes contain large numbers of tandemly repeated α-satellite sequences. These sequences are covered with constitutive heterochromatin which is enriched in trimethylation of histone H3 on lysine 9 (H3K9me3). Although well studied using artificial...

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Bibliographic Details
Main Authors: Sheldon Decombe, François Loll, Laura Caccianini, Kévin Affannoukoué, Ignacio Izeddin, Julien Mozziconacci, Christophe Escudé, Judith Lopes
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Epigenetics & Chromatin
Subjects:
Centromere
Chromosomal instability
Epigenetics
Heterochromatin
Histone methylation
Online Access:https://doi.org/10.1186/s13072-021-00410-x

Internet

https://doi.org/10.1186/s13072-021-00410-x

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