Antiproliferative and Antimigration Activities of Fluoro-Neplanocin A via Inhibition of Histone H3 Methylation in Triple-Negative Breast Cancer

Antiproliferative and Antimigration Activities of Fluoro-Neplanocin A via Inhibition of Histone H3 Methylation in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is among the most aggressive and potentially metastatic malignancies. Most affected patients have poor clinical outcomes due to the lack of specific molecular targets on tumor cells. The upregulated expression of disruptor of telomeric silencing 1-like (DOT1L), a...

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Bibliographic Details
Main Authors: Woong Sub Byun, Won Kyung Kim, Ji-seong Yoon, Dnyandev B. Jarhad, Lak Shin Jeong, Sang Kook Lee
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
triple-negative breast cancer
DOT1L
histone H3 lysine methylation
H3K79me2
fluoro-neplanocin A
metastasis
Online Access:https://www.mdpi.com/2218-273X/10/4/530

Internet

https://www.mdpi.com/2218-273X/10/4/530

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