Mechanistic prediction of food effects for Compound A tablet using PBPK model

Mechanistic prediction of food effects for Compound A tablet using PBPK model

Physiologically based pharmacokinetic (PBPK) modeling has been extensively used to study the factors of effect drug absorption, distribution, metabolize and extraction progress in human. In this study, Compound A(CPD A) is a BCS Class II drug, which has been extensive applied in clinical as lipid-lo...

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Bibliographic Details
Main Authors: Xueqing Li, Lei Shi, Xiuling Tang, Qinghui Wang, Lun Zhou, Wei Song, Zhijun Feng, Jie Ge, Jian Kang Li, Lin Yang, Aidong Wen, Yan Zhang
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Saudi Journal of Biological Sciences
Subjects:
Food effects
PBPK
ACAT
Prediction
Pharmacokinetic
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X17300414

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http://www.sciencedirect.com/science/article/pii/S1319562X17300414

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