Molecular Mechanisms of DNA Replication Checkpoint Activation

The major challenge of the cell cycle is to deliver an intact, and fully duplicated, genetic material to the daughter cells. To this end, progression of DNA synthesis is monitored by a feedback mechanism known as replication checkpoint that is untimely linked to DNA replication. This signaling pathw...

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Bibliographic Details
Main Authors: Bénédicte Recolin, Siem van der Laan, Nikolay Tsanov, Domenico Maiorano
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Genes
Subjects:
ATR
Online Access:http://www.mdpi.com/2073-4425/5/1/147