A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness

A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness

Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the covalent CaM inhibitor ophiobolin A (OphA) can potently inhibit K-Ras stemness activity. However, OphA, a fungus-derived natu...

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Bibliographic Details
Main Authors: Sunday Okutachi, Ganesh Babu Manoharan, Alexandros Kiriazis, Christina Laurini, Marie Catillon, Frank McCormick, Jari Yli-Kauhaluoma, Daniel Abankwa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
K-Ras
calmodulin
covalent inhibitor
cancer stem cell (CSC)
BRET
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.665673/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.665673/full

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