Combined Treatment with Low Concentrations of Decitabine and SAHA Causes Cell Death in Leukemic Cell Lines but Not in Normal Peripheral Blood Lymphocytes

Combined Treatment with Low Concentrations of Decitabine and SAHA Causes Cell Death in Leukemic Cell Lines but Not in Normal Peripheral Blood Lymphocytes

Epigenetic therapy reverting aberrant acetylation or methylation offers the possibility to target preferentially tumor cells and to preserve normal cells. Combination epigenetic therapy may further improve the effect of individual drugs. We investigated combined action of demethylating agent decitab...

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Bibliographic Details
Main Authors:	Barbora Brodská, Aleš Holoubek, Petra Otevřelová, Kateřina Kuželová
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2013/659254

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