Concurrent somatic KRAS mutation and germline 10q22.3-q23.2 deletion in a patient with juvenile myelomonocytic leukemia, developmental delay, and multiple malformations: a case report

Concurrent somatic KRAS mutation and germline 10q22.3-q23.2 deletion in a patient with juvenile myelomonocytic leukemia, developmental delay, and multiple malformations: a case report

Abstract Background The proto-oncogene KRAS performs an essential function in normal tissue signaling, and the mutation of KRAS gene is a key step in the development of many cancers. Somatic KRAS mutations are often detected in patients with solid and non-solid tumors, whereas germline KRAS mutation...

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Bibliographic Details
Main Authors: Ruen Yao, Tingting Yu, Yufei Xu, Guoqiang Li, Lei Yin, Yunfang Zhou, Jian Wang, Zhilong Yan
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Medical Genomics
Subjects:
KRAS
10q deletion
Juvenile myelomonocytic leukemia
Developmental delay
Whole-exome sequencing
Online Access:http://link.springer.com/article/10.1186/s12920-018-0377-3

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http://link.springer.com/article/10.1186/s12920-018-0377-3

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