AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions

Changes in AMPAR localization can control the strength of synaptic transmission. Here, the authors show that the interactions of TARP γ8 and the AMPAR N-terminal domain work together to regulate receptor accumulation and positioning at the post-synapse of mouse hippocampal CA1 neurons.

Bibliographic Details
Main Authors: Jake F. Watson, Alexandra Pinggera, Hinze Ho, Ingo H. Greger
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25281-4