Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation

Translational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the ribosome and EF-G to induce +1 frameshifting during t...

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Main Authors:	Gabriel Demo, Howard B. Gamper, Anna B. Loveland, Isao Masuda, Christine E. Carbone, Egor Svidritskiy, Ya-Ming Hou, Andrei A. Korostelev
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24911-1

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spelling	doaj-9e96fbbefbf946cca2e64e5aa10017b32021-08-01T11:38:30ZengNature Publishing GroupNature Communications2041-17232021-07-0112111210.1038/s41467-021-24911-1Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocationGabriel Demo0Howard B. Gamper1Anna B. Loveland2Isao Masuda3Christine E. Carbone4Egor Svidritskiy5Ya-Ming Hou6Andrei A. Korostelev7RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical SchoolDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityRNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical SchoolDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityRNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical SchoolRNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical SchoolDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityRNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical SchoolTranslational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the ribosome and EF-G to induce +1 frameshifting during the translocation step.https://doi.org/10.1038/s41467-021-24911-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gabriel Demo Howard B. Gamper Anna B. Loveland Isao Masuda Christine E. Carbone Egor Svidritskiy Ya-Ming Hou Andrei A. Korostelev
spellingShingle	Gabriel Demo Howard B. Gamper Anna B. Loveland Isao Masuda Christine E. Carbone Egor Svidritskiy Ya-Ming Hou Andrei A. Korostelev Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation Nature Communications
author_facet	Gabriel Demo Howard B. Gamper Anna B. Loveland Isao Masuda Christine E. Carbone Egor Svidritskiy Ya-Ming Hou Andrei A. Korostelev
author_sort	Gabriel Demo
title	Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation
title_short	Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation
title_full	Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation
title_fullStr	Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation
title_full_unstemmed	Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation
title_sort	structural basis for +1 ribosomal frameshifting during ef-g-catalyzed translocation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-07-01
description	Translational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the ribosome and EF-G to induce +1 frameshifting during the translocation step.
url	https://doi.org/10.1038/s41467-021-24911-1
work_keys_str_mv	AT gabrieldemo structuralbasisfor1ribosomalframeshiftingduringefgcatalyzedtranslocation AT howardbgamper structuralbasisfor1ribosomalframeshiftingduringefgcatalyzedtranslocation AT annabloveland structuralbasisfor1ribosomalframeshiftingduringefgcatalyzedtranslocation AT isaomasuda structuralbasisfor1ribosomalframeshiftingduringefgcatalyzedtranslocation AT christineecarbone structuralbasisfor1ribosomalframeshiftingduringefgcatalyzedtranslocation AT egorsvidritskiy structuralbasisfor1ribosomalframeshiftingduringefgcatalyzedtranslocation AT yaminghou structuralbasisfor1ribosomalframeshiftingduringefgcatalyzedtranslocation AT andreiakorostelev structuralbasisfor1ribosomalframeshiftingduringefgcatalyzedtranslocation
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Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation

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