Molecular and Dynamic Evaluation of Proteins Related to Resistance to Neoadjuvant Treatment with Chemoradiotherapy in Circulating Tumor Cells of Patients with Locally Advanced Rectal Cancer

Molecular and Dynamic Evaluation of Proteins Related to Resistance to Neoadjuvant Treatment with Chemoradiotherapy in Circulating Tumor Cells of Patients with Locally Advanced Rectal Cancer

The heterogeneity of response to neoadjuvant chemoradiotherapy (NCRT) is still a challenge in locally advanced rectal cancer (LARC). The evaluation of thymidylate synthase (TYMS) and RAD23 homolog B (RAD23B) expression in circulating tumor cells (CTCs) provides complementary clinical information. CT...

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Bibliographic Details
Main Authors: Virgílio Souza e Silva, Emne Ali Abdallah, Bianca de Cássia Troncarelli Flores, Alexcia Camila Braun, Daniela de Jesus Ferreira Costa, Anna Paula Carreta Ruano, Vanessa Alves Gasparini, Maria Letícia Gobo Silva, Gustavo Gomes Mendes, Laura Carolina Lopez Claro, Vinicius Fernando Calsavara, Samuel Aguiar Junior, Celso Abdon Lopes de Mello, Ludmilla Thomé Domingos Chinen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
locally advanced rectal carcinoma
neoadjuvant chemoradiation
liquid biopsy
circulating tumor cell
RAD23B
Online Access:https://www.mdpi.com/2073-4409/10/6/1539

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https://www.mdpi.com/2073-4409/10/6/1539

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