Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells

Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells

Withaferin A (WFA) is one of the most active steroidal lactones with reactive oxygen species (ROS) modulating effects against several types of cancer. ROS regulation involves selective killing. However, the anticancer and selective killing effects of WFA against oral cancer cells remain unclear. We...

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Bibliographic Details
Main Authors: Hsueh-Wei Chang, Ruei-Nian Li, Hui-Ru Wang, Jing-Ru Liu, Jen-Yang Tang, Hurng-Wern Huang, Yu-Hsuan Chan, Ching-Yu Yen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Physiology
Subjects:
oral cancer
selective killing
apoptosis
oxidative stress
withaferin A
N-acetylcysteine
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00634/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00634/full

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