Changes in the peripheral blood gene expression profile induced by 3 months of valproate treatment in patients with newly diagnosed epilepsy

Changes in the peripheral blood gene expression profile induced by 3 months of valproate treatment in patients with newly diagnosed epilepsy

Valproic acid (VPA) is a widely used antiepileptic drug with a broad range of effects and broad clinical efficacy. As a well-known histone deacetylase (HDAC) inhibitor, VPA regulates epigenetic programming by altering the expression of many genes. The aim of study was to analyze differences in gene...

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Bibliographic Details
Main Authors: Aleksei eRakitin, Sulev eKõks, Ene eReimann, Ele ePrans, Sulev eHaldre
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Neurology
Subjects:
Epilepsy
Gene Expression
Valproic Acid
valproate
teratogenicity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00188/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00188/full

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