Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC

Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC

Abstract Pyruvate kinase M2 as a key rate-limiting enzyme in glycolysis, it plays a critical role in metabolic reprogramming and carcinogenesis. However, whether PKM2 can promote immunosuppressive microenvironment formation remains unknown in head and neck squamous cell carcinoma (HNSCC). PKM2 expre...

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Bibliographic Details
Main Authors: Hanyue Chang, Qiaoshi Xu, Jiayi Li, Mingyu Li, Zhiyuan Zhang, Hailong Ma, Xi Yang
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03990-4

Internet

https://doi.org/10.1038/s41419-021-03990-4

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