Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

<p>Abstract</p> <p>Background</p> <p>The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) is expressed in neuropeptide Y and proopiomelanocortin (POMC) neurons in the arcuate nucleus, target neurons in t...

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Bibliographic Details
Main Authors: Xia Zefeng, Fritze Danielle, Zhang Chao, Wu Xiaobin, Zhang Weizhen, Chai Biaoxin, Li Ji-Yao, Patterson Cam, Mulholland Michael W
Format: Article
Language:English
Published: BMC 2011-09-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/12/95

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http://www.biomedcentral.com/1471-2202/12/95

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