Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity

One of the molecular hallmarks of amyloidoses is ordered protein aggregation involving the initial formation of soluble protein oligomers that eventually grow into insoluble fibrils. The identification and characterization of molecular species critical for amyloid fibril formation and disease develo...

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Bibliographic Details
Main Authors: Ana Frangolho, Bruno E. Correia, Daniela C. Vaz, Zaida L. Almeida, Rui M. M. Brito
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
TTR
Online Access:https://www.mdpi.com/1420-3049/25/23/5698