Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

Abstract Background Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured plasma levels of syndecan-1, a marker for glycocalyx degradation. Methods...

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Bibliographic Details
Main Authors: Laura S. Murphy, Nancy Wickersham, J. Brennan McNeil, Ciara M. Shaver, Addison K. May, Julie A. Bastarache, Lorraine B. Ware
Format: Article
Language:English
Published: SpringerOpen 2017-10-01
Series:Annals of Intensive Care
Subjects:
Syndecan-1
Glycocalyx
Sepsis
Acute respiratory distress syndrome (ARDS)
Online Access:http://link.springer.com/article/10.1186/s13613-017-0325-y

Internet

http://link.springer.com/article/10.1186/s13613-017-0325-y

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