Development of carrier-free nanocrystals of poorly water-soluble drugs by exploring metastable zone of nucleation

There has been increasing interest in research and development of nanocrystals for the delivery of poorly water-soluble drugs that can be directly produced from solution. Compared with traditional carrier-based or encapsulation designs, drug nanocrystals circumvent possible side-effects due to carri...

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Bibliographic Details
Main Authors: Xiaoting Ren, Jianping Qi, Wei Wu, Zongning Yin, Tonglei Li, Yi Lu
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Acta Pharmaceutica Sinica B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383518301229