A hypomorphic lsd1 allele results in heart development defects in mice.

A hypomorphic lsd1 allele results in heart development defects in mice.

Lysine-specific demethylase 1 (Lsd1/Aof2/Kdm1a), the first enzyme with specific lysine demethylase activity to be described, demethylates histone and non-histone proteins and is essential for mouse embryogenesis. Lsd1 interacts with numerous proteins through several different domains, most notably t...

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Bibliographic Details
Main Authors: Thomas B Nicholson, Anup K Singh, Hui Su, Sarah Hevi, Jing Wang, Jeff Bajko, Mei Li, Reginald Valdez, Margaret Goetschkes, Paola Capodieci, Joseph Loureiro, Xiaodong Cheng, En Li, Bernd Kinzel, Mark Labow, Taiping Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3634827?pdf=render

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http://europepmc.org/articles/PMC3634827?pdf=render

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