Methylseleninic Acid Sensitizes Ovarian Cancer Cells to T-Cell Mediated Killing by Decreasing PDL1 and VEGF Levels

Methylseleninic Acid Sensitizes Ovarian Cancer Cells to T-Cell Mediated Killing by Decreasing PDL1 and VEGF Levels

Redox active selenium (Se) compounds at sub toxic doses act as pro-oxidants with cytotoxic effects on tumor cells and are promising future chemotherapeutic agents. However, little is known about how Se compounds affect immune cells in the tumor microenvironment. We demonstrate that the inorganic Se...

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Bibliographic Details
Main Authors: Deepika Nair, Emelie Rådestad, Prajakta Khalkar, Nuria Diaz-Argelich, Axel Schröder, Charlotte Klynning, Johanna Ungerstedt, Michael Uhlin, Aristi P. Fernandes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Oncology
Subjects:
selenium
methylseleninic acid
PDL1
VEGF
HIF-1α
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00407/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00407/full

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