Pyrin Modulates the Intracellular Distribution of PSTPIP1.

PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne), an autoinflammatory disease. PSTPIP1 binds to pyrin and mutations in pyrin result in fami...

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Main Authors: Andrea L Waite, Philip Schaner, Neil Richards, Banu Balci-Peynircioglu, Seth L Masters, Susannah D Brydges, Michelle Fox, Arthur Hong, Engin Yilmaz, Daniel L Kastner, Ellis L Reinherz, Deborah L Gumucio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2702820?pdf=render